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Depression’s defining symptom is anhedonia, the inability to feel, anticipate, or pursue pleasure. Chronic stress depletes the mesolimbic system of dopamine, generating anhedonia. The link between childhood adversity and adult depression involves both organizational effects on the developing mesolimbic system and elevated adult glucocorticoid levels, which can deplete dopamine.

Robert M. Sapolsky Quote: “Depression’s defining symptom is anhedonia, the inability to feel, anticipate, or pursue pleasure. Chronic stress depletes the mesolimbic system of dopamine, generating anhedonia. The link between childhood adversity and adult depression involves both organizational effects on the developing mesolimbic system and elevated adult glucocorticoid levels, which can deplete dopamine.”

“Depression’s defining symptom is anhedonia, the inability to feel, anticipate, or pursue pleasure. Chronic stress depletes the mesolimbic system of dopamine, generating anhedonia. The link between childhood adversity and adult depression involves both organizational effects on the developing mesolimbic system and elevated adult glucocorticoid levels, which can deplete dopamine.”

Robert M. Sapolsky

Robert M. Sapolsky Quote: “Depression’s defining symptom is anhedonia, the inability to feel, anticipate, or pursue pleasure. Chronic stress depletes the mesolimbic system of dopamine, generating anhedonia. The link between childhood adversity and adult depression involves both organizational effects on the developing mesolimbic system and elevated adult glucocorticoid levels, which can deplete dopamine.”
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