Top 60 Seth MacFarlane Quotes (2025 Update)

1. “The only reason we die, is because we accept death as an inevitability.”

— Seth MacFarlane

2. “I hate people who say ‘Just to play devil’s advocate.’”

— Seth MacFarlane

3. “I do not believe in God. I’m an atheist. I consider myself a critical thinker, and it fascinates me that in the 21st century most people still believe in, as George Carlin puts it, ‘the invisible man living in the sky’”

— Seth MacFarlane

4. “I was a huge ‘Star Trek’ fan. I loved the ‘Twilight Zone’ growing up. In the future, I hope to create some thoughtful, sci-fi drama.”

— Seth MacFarlane

5. “You gotta keep the funny intact.”

— Seth MacFarlane

6. “I have a car that I like – an Aston Martin – for Sunday drives in the country.”

— Seth MacFarlane

7. “The only problem is time.”

— Seth MacFarlane

8. “I love the English. My God, they brought us ‘Benny Hill,’ ‘Monty Python,’ ‘The Office,’ Neville Chamberlain.”

— Seth MacFarlane

9. “When astrology was conceived, all of the celestial bodies were in different places. So if you’re a Sagittarius now, I guess you would have been a Capricorn 2,000 years ago.”

— Seth MacFarlane

10. “I’m the guy in the crowd making fun of the hero’s shirt.”

— Seth MacFarlane

11. “Whoever invented spray cheese had to have been a Harvard guy.”

— Seth MacFarlane

12. “Evolution doesn’t care whether you believe in it or not, no more than gravity does. I want to rekindle excitement over what we’ve achieved as a species with the space program. We can’t afford to regress back to the days of superstition.”

— Seth MacFarlane

13. “There have to be people who are vocal about the advancement of knowledge over faith.”

— Seth MacFarlane

14. “If a song is funny and absurd, and it sounds great, it’s just going to be that much funnier. And there’s no better example of that than ‘Monty Python.’”

— Seth MacFarlane

15. “Chris Elliott could read the phonebook and he’s funny.”

— Seth MacFarlane

16. “Adults acting like children and children acting like adults is generally a pretty reliable comic device.”

— Seth MacFarlane

17. “I’m wide open to getting married, but actors are not easy people to date. You end up sharing that person with this other mistress that is their career. I very much like the traditional courtship method of making a date. That’s what they do in normal places, but Hollywood’s not normal.”

— Seth MacFarlane

18. “The two symbols of the Republican Party: an elephant, and a big fat white guy who is threatened by change.”

— Seth MacFarlane

19. “If you literally believe the story of Noah, try getting a monkey in a car during a storm. It’s almost impossible. Now do it one more time.”

— Seth MacFarlane

20. “I don’t smoke much pot anymore.”

— Seth MacFarlane

21. “Everybody in my family had a real sick, twisted sense of humor. Most of the jokes we make in our house, we would just never even dream of making anywhere else. Just sick, horrible stuff. That wasn’t anything new to college.”

— Seth MacFarlane

22. “The relationship between Aquaman and Aqualad should be investigated.”

— Seth MacFarlane

23. “What makes me happy is just keeping my brain challenged and stimulated and on its toes.”

— Seth MacFarlane

24. “There are times when I’m under the weather and the corporate machine tries to put me in the recording booth anyway. It’s always up to me to say, ‘Guys, listen to me, listen to what I sound like. I’m not myself.’”

— Seth MacFarlane

25. “I tend to lean more towards the Westerns of the 40s and 50s as opposed to the 60s and 70s. They get a little too drab for me when you get into the Spaghetti Western era. I love the John Ford movies. I love the music. I love the scope.”

— Seth MacFarlane

26. “The worst thing to happen at the Oscars would be if nothing happened. You want something unscripted, something to riff on, something kinda out there.”

— Seth MacFarlane

27. “Believe it or not, I have about the same success rate as anyone else. Sometimes you hit, sometimes you miss.”

— Seth MacFarlane

28. “Every woman’s innate ability to let anything go.”

— Seth MacFarlane

29. “I wrote on a show called Johnny Bravo when I was at Hanna-Barbera.”

— Seth MacFarlane

30. “Fox is notorious for having a very thick skin about taking shots at themselves.”

— Seth MacFarlane

31. “Every year, the Friday before the new Saturday-morning shows would premiere, the networks would do this big preview special, and I was always glued to the TV. As horrible as they were, they were entertaining at the time. There was a lot of showmanship from the networks based around the new lineup.”

— Seth MacFarlane

32. “The Simpsons are ugly-looking, and they should be. That’s what works. That’s one of the things that’s funny.”

— Seth MacFarlane

33. “My dad always played Anne Murray in the car on the way to the dump when I was a kid.”

— Seth MacFarlane

34. “I did a lot of theater when I was in high school and college. I also did stand-up in college, so it was always part of what I did.”

— Seth MacFarlane

35. “I spent my entire childhood in the same town, in Kent. I went to grade school there. There was a boarding school that my mother taught at, called – appropriately enough – Kent School, that I went to. Yeah, pretty much my entire childhood was spent in that town.”

— Seth MacFarlane

36. “Denzel Washington has a great sense of humor. He did all those ‘Nutty Professor’ movies.”

— Seth MacFarlane

37. “There are things about the single lifestyle that are very appealing.”

— Seth MacFarlane

38. “I was a big Fred Flintstone fan.”

— Seth MacFarlane

39. “I think at times I read too much of my own press. I wish I was better at taking in how great my life is, but that’s surprisingly elusive. I tend to be very hard on myself and insecure about failing no matter what happens.”

— Seth MacFarlane

40. “I don’t gravitate toward any particular genre. I like to do things that interest me, regardless of genre. I’ve had a blast doing Cosmos, and I’m said that it’s coming to an end. I would like to do something else like that.”

— Seth MacFarlane

41. “When ‘Family Guy’ started, we wanted to make it more like a sitcom. And there was very little music.”

— Seth MacFarlane

42. “I still do a lot of drawing on a daily basis.”

— Seth MacFarlane

43. “I’m big on the importance of science, particularly right now at this point in time when there’s sort of a systematic rejection of science by a lot of people in America.”

— Seth MacFarlane

44. “Nobody sets out to offend or shock for the sake of shocking. You set out to get laughs.”

— Seth MacFarlane

45. “At one point, I was hell-bent on being a Disney animator, and sort of got over that in college and wanted to do my own stuff. You know, towards the end of college I had actually planned to go to the Boston Conservatory of Music for musical theater.”

— Seth MacFarlane

46. “If something is shocking without being funny it’s hard to justify.”

— Seth MacFarlane

47. “I distrust all television doctors.”

— Seth MacFarlane

48. “Ta-da! A colossal prick!”

— Seth MacFarlane

49. “Sarah Palin is very pro-life of course, unless the life is that of an Iraqi civilian or a wolf running frantically from a roaring helicopter while being strafed with ribbons of automatic weapons fire.”

— Seth MacFarlane

50. “The trend today is vampires, zombies, angels, all the stuff that puts me right to sleep. It’s too bad because it’s so much less interesting than the diversity of stories you can tell with science.”

— Seth MacFarlane